Histone Methyltransferase - Selective
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
- B6182 GSK591Target: PRMTSummary: PRMT5抑制剂
- B4989 EPZ015666Target: Protein Arginine MethyltransferasesSummary: PRMT5抑制剂
- B4875 PFI-21 CitationTarget: SETD7Summary: SETD7甲基转移酶抑制剂
- B7757 UNC 0642Target: G9a|GLPSummary: G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂
- B1581 EPZ004777 HClTarget: DOT1LSummary: DOT1L抑制剂
- B1255 AZ505Target: SMYD2Summary: SMYD2抑制剂
- B1583 UNC19992 CitationTarget: EZH2|EZH1Summary: EZH2抑制剂
- A8221 EPZ-64385 CitationSummary: EZH2抑制剂
- A1909 BIX 01294Target: G9aSummary: G9a和GLP抑制剂
- A1905 3-Deazaneplanocin,DZNep6 Citation中文名: 3-去氮腺嘌呤ATarget: HydrolaseSummary: S-腺苷高半胱氨酸和EZH2抑制剂。