Histone Methyltransferase
Histone methyltransferases are a group of enzymes that catalyze the methylation of histone lysine and arginine by adding methyl groups to specific histone arginine or lysine residues. Histone methyltransferaes can be classified into 3 classes, including SET domain lysine methyltransferases, non-SET domain lysine methyltransferases and arginine methyltransferases (PRMTs), all of which use S-adenosylmethionine as a cosubstrate for the transfer of the methyl group. Aberrant histone methylation has been associated with a wide range of human cancers (such as hematological malignancies), which leads to the development of novel cancer chemotherapies targeting cancer-associated histone methyltransferases (more than 20 lysine methyltransferases and 9 arginine methyltransferases in humans).
- B1582 MM-1021 CitationSummary: 高亲和力肽类MLL1抑制剂
- A8221 EPZ-64385 CitationSummary: EZH2抑制剂
- A4503 UNC 0224Summary: G9a组蛋白甲基转移酶抑制剂
- A4504 UNC 0646Summary: G9a和GLP抑制剂
- A4502 Chaetocin中文名: 毛壳素Summary: SUV39H1抑制剂
- A1146 Histone-H2A-(107-122)-Ac-OHSummary: 组蛋白H2A肽
- A1914 UNC06381 CitationSummary: 有效的G9a/GLP HMTase选择性抑制剂
- A1909 BIX 01294Target: G9aSummary: G9a和GLP抑制剂
- A1908 AMI-1Summary: PRMT1抑制剂
- A1905 3-Deazaneplanocin,DZNep6 Citation中文名: 3-去氮腺嘌呤ATarget: HydrolaseSummary: S-腺苷高半胱氨酸和EZH2抑制剂。