Histone Demethylases
Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone. So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.
- B5879 GSK28795521 CitationTarget: LSDSummary: LSD1抑制剂
- B5959 GSK J4 free baseSummary: 组蛋白去甲基化酶JMJD3/UTX抑制剂
- B4983 GSK-LSD1 2HClSummary: LSD1抑制剂
- B4930 TC-E 5002Target: KDMSummary: 选择性组蛋白去甲基化酶KDM2/7亚家族抑制剂
- B4894 SP2509Target: Histone DemethylasesSummary: 新型LSD1拮抗剂
- B4891 ML3241 CitationSummary: JMJD2去甲基化酶抑制剂
- B5686 GSK J5Summary: GSK J4(KDM抑制剂)的无活性异构体
- B5685 GSK J2Summary: GSK J1(JMJD3(KDM6B)和UTX(KDM6A)抑制剂)的无活性对照
- B5607 IOX 11 CitationSummary: 组蛋白去甲基化酶JMJD抑制剂
- B7514 Tranylcypromine hydrochloride1 CitationSummary: 单胺氧化酶抑制剂