Histone Acetyltransferases
Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
- B7250 YM 750Summary: 酰基辅酶A:胆固醇酰基转移酶(ACAT)抑制剂
- B7241 VULM 1457Summary: 酰基辅酶A:胆固醇酰基转移酶(ACAT)抑制剂
- B6987 CI 976Summary: 酰基辅酶A:胆固醇酰基转移酶(ACAT)抑制剂
- B1577 C6461 CitationTarget: p300Summary: HAT p300-CBP抑制剂
- B1602 Donepezil HCl中文名: 盐酸多奈哌齐Target: AChESummary: AChE抑制剂
- B3276 MG 1492 CitationSummary: HAT抑制剂
- A4492 NU 9056Target: Histone Acetyltransferases (HATs)Summary: KAT5(Tip60)HAT抑制剂