HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
- A4098 PCI-24781 (CRA-024781)Target: Histone Deacetylases (HDACs)Summary: Pan-HDAC抑制剂
- A4097 CUDC-907中文名: 非美诺司他Target: Histone Deacetylases (HDACs)|PI3KSummary: PI3K/HDAC抑制剂
- A4096 Belinostat (PXD101)2 Citation中文名: 贝利司他Target: Histone Deacetylases (HDACs)Summary: 羟肟酸型HDAC抑制剂
- A4095 Pracinostat (SB939)2 CitationTarget: Histone Deacetylases (HDACs)Summary: Pan-HDAC抑制剂
- A4094 MC15683 CitationTarget: Histone Deacetylases (HDACs)Summary: II类HDAC抑制剂
- A4108 Resminostat (RAS2410)1 Citation中文名: 瑞诺司他,瑞米诺司他Summary: 强效HDAC抑制剂
- A4107 Sodium Phenylbutyrate中文名: 苯基丁酸钠Target: Histone Deacetylases (HDACs)Summary: 组蛋白去乙酰化酶抑制剂
- A4106 Scriptaid1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4093 ITF2357 (Givinostat)2 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC抑制剂
- A4092 CUDC-1011 CitationTarget: Histone Deacetylases (HDACs)|EGFR|ErbBSummary: 多靶点HDAC抑制剂