Bromodomain
Bromodomains are a family of evolutionarily conserved protein modules of approximately 110 amino acids that have been found in chromatin-associated proteins as well as nuclear histone acetyltransferases (HATs). Besides its role in chromatin remodeling, recent studies have identified that bromodomains, as acetyl-lysine binding domains, are able to recognize and bind ε–N-acetylated lysine residues in histone and non-histone proteins. The nuclear magnetic resonance (NMR) spectroscopic analysis reveals that the chemical structure of bromodomains, consisting of four left-handed α-helices (including αZ, αA, αB and αC) connected by two loops (ZA and BC loops), forms a deep hydrophobic cavity serving as the acetyl-lysine recognition site.
- A3445 GSK 525768ASummary: I-BET-762的无活性立体异构体
- A1910 Bromodomain Inhibitor, (+)-JQ138 CitationTarget: BromodomainsSummary: BET bromodomain抑制剂。
- A4186 Bromosporine1 CitationTarget: BromodomainsSummary: Bromodomain抑制剂
- A4184 PFI-1 (PF-6405761)1 CitationTarget: BromodomainsSummary: BET抑制剂
- A8181 (-)-JQ14 CitationTarget: BromodomainsSummary: (+)-JQ1的立体异构体,可作为阴性对照物。