Chromatin/Epigenetics
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- C3095 N-OxalylglycineSummary: α-酮戊二酸依赖性酶(包括JMJD2A,JMJD2C和JMJD2E)的细胞渗透性抑制剂
- C3898 Cantharidic Acid (sodium salt)Summary: PP1和PP2A抑制剂
- C3888 JGB1741Summary: SIRT1抑制剂
- C3630 Lysine-specific Demethylase Inhibitor (1C)Summary: 赖氨酸特异性去甲基化酶抑制剂
- C3607 PTP Inhibitor I中文名: PTP抑制剂一Summary: 酪氨酸磷酸酶(PTP)抑制剂
- C3584 PBITSummary: JARID1家族去甲基化酶抑制剂
- C3552 4'-bromo-Resveratrol1 CitationSummary: Sirt1和Sirt3抑制剂
- C3591 PTP Inhibitor II中文名: PTP抑制剂二Summary: 蛋白酪氨酸磷酸酶(PTP)抑制剂
- C3503 MS023 (hydrochloride)Summary: I型PRMTs抑制剂
- C3076 AZD 5153Summary: 可口服的BET蛋白BRD4的二价抑制剂