Chromatin/Epigenetics
Epigenetics is the heritable modifications in gene expression that is not associated with changes in DNA sequence. Epigenetic modifications occur mostly on DNA or on the histone octamer. There are several types of epigenetics modifications, DNA methylation by DNA-methyl transferase (DNMT) and covalent modification of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination). Histone acetylation by histone acetyltransferases (HATs) is involved in transcriptional activation, whereas histone deacetylation by histone deacetylases (HDACs) is connected with transcriptional repression. Histone demethylation is associated with lysine-specific demethylase (LSD) and JmjC domain containing histone demethylase (JHDM).
The nucleosome is consisted of four histone proteins (H2A, H2B, H3, and H4), they are primary building block of chromatin. The addition and removal of specific chemical groups refers to as epigenetic marks, it regulates chromatin structure and affects gene expression. Moreover, RNA is intimately involved in the formation of a repressive chromatin state.
Epigenetic mechanism responds to environmental changes at the cellular level and thus influences cellular plasticity. Chromatin and epigenetic regulation play a significant role in the programming of the genome during development and stress response, defects in epigenetics can lead to cancer, inflammation and metabolic disorders etc.
- C5180 JFD00244Summary: SIRT2抑制剂
- C5162 BizineSummary: LSD1抑制剂
- C5042 MS37452Summary: CBX7染色体结合H3K27me3的竞争性抑制剂
- C5000 HAT Inhibitor IISummary: 组蛋白乙酰转移酶p300的抑制剂
- C4834 (S)-PFI-2 (hydrochloride)Summary: (R)-PFI 2 hydrochloride的阴性对照
- C4614 bpV(HOpic) (potassium salt, technical grade)Summary: 蛋白酪氨酸磷酸酶(PTPs)抑制剂
- C4672 IOX4Summary: PHD2抑制剂
- C4401 PTP Inhibitor IVSummary: PTP抑制剂
- C4445 2-D08Summary: Sumo化抑制剂
- C4347 β-Glycerophosphate (sodium salt hydrate)中文名: β-甘油磷酸钠盐水合物Summary: 蛋白磷酸酶抑制剂