Cell Cycle/Checkpoint - Reversible
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B5881 RI-2Target: RAD51Summary: RAD51抑制剂
- A8885 Ro 33064 CitationTarget: Cyclin-Dependent KinasesSummary: CDK1抑制剂
- A8625 CP-466722Target: ATMSummary: ATM抑制剂
- A8441 GSK4613643 CitationTarget: PLKSummary: Plk1抑制剂
- A8336 KU-600192 CitationTarget: ATM/ATRSummary: ATM激酶抑制剂
- A5919 AZD7762Target: ChkSummary: ATP竞争性的检查点激酶抑制剂
- A3336 CVT-3131 CitationTarget: Cyclin-Dependent KinasesSummary: Cdk2抑制剂
- A4128 PF-03814735Target: Aurora KinasesSummary: Aurora A/B抑制剂
- A4127 GSK1070916Target: Aurora KinasesSummary: Aurora B/C抑制剂