Cell Cycle/Checkpoint - Prostate Cancer
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- B2157 Cabazitaxel3 Citation中文名: 卡巴他赛Target: Microtubule/TubulinSummary: 微管相关抑制剂
- B1288 RigosertibTarget: PI3K|PLKSummary: PI3K/PLK1抑制剂
- A8300 ZCL2781 CitationTarget: Cdc42Summary: Cdc42抑制剂
- A5343 Ispinesib (SB-715992)中文名: 伊斯平斯Target: KspSummary: 驱动蛋白纺锤体蛋白(KSP)抑制剂
- A4118 Hesperadin1 Citation中文名: 橙皮甙,橙皮苷Target: Aurora KinasesSummary: Aurora B抑制剂