Cell Cycle/Checkpoint
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- C5813 CFI-400945Summary: polo样激酶4(PLK4)的口服选择性抑制剂
- C5188 Eg5-ISummary: Eg5的有效抑制剂
- B7855 AlsterpaulloneSummary: CDKs和GSK3β抑制剂
- C4413 cis-trismethoxy ResveratrolSummary: 抗有丝分裂药物
- C4459 Moniliformin (sodium salt)中文名: 串珠镰刀菌素钠盐Summary: 诱导有丝分裂停滞在中期
- C4738 MLS-573151Summary: Cdc42抑制剂
- C4254 3-(4-Pyridyl)indoleSummary: ROCK-I抑制剂
- C4390 Cytochalasin JSummary: 改变有丝分裂纺锤体微管组织和动力学结构
- C4226 Phomopsin A中文名: 促微管解聚 ASummary: 结合β-微管蛋白的环状六肽霉菌毒素
- C4040 OlomoucineSummary: cdk抑制剂