TNF-α - Animal Experiments
Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.
- A4216 Thalidomide中文名: 沙利度胺Target: Ubiquitin E3 LigasesSummary: 免疫调节剂,镇静药,血管生成抑制剂
- A4213 Necrostatin-15 CitationTarget: RIP kinasesSummary: RIP1抑制剂
- A4212 Pomalidomide (CC-4047)中文名: 泊马度胺Summary: 抗肿瘤/抗血管生成的免疫调制剂
- A4211 Lenalidomide (CC-5013)中文名: 来那度胺Target: angiogenesisSummary: 抗肿瘤药物,抑制血管生成。
- A2604 Celastrol中文名: 雷公藤红素Target: ProteasomeSummary: 抗氧化、抗炎和免疫抑制剂