p53 - Cancer
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
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- A8804 AMG2322 CitationTarget: p53-MDM2 interactionSummary: p53-MDM2抑制剂
- A4482 Pifithrin-μ1 CitationTarget: Autophagy|p53|HSP70Summary: p53结合抑制剂,抗凋亡。
- A4483 PRIMA-1Target: p53Summary: BAX抑制剂
- A4456 Plumbagin中文名: 白花丹素Summary: 抗癌剂
- A3762 RG71125 CitationTarget: MDM2Summary: MDM2抑制剂
- A4204 JNJ-26854165 (Serdemetan)1 CitationTarget: p53|HDM2 ubiquitin ligaseSummary: P53激活剂,阻断Mdm2-p53相互作用。
- A4228 Nutlin-3Target: MDM2Summary: MDM2 拮抗剂
- A4208 NSC 319726Target: p53Summary: 突变型p53的活性剂