p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- A4483 PRIMA-1Target: p53Summary: BAX抑制剂
- A4481 PhiKan 083Target: p53Summary: P53稳定剂
- A4479 MIRA-1Summary: 野生型p53构象/细胞功能的恢复剂
- A4478 HLI 373Summary: Hdm2泛素连接酶(E3)抑制剂
- A4476 CP 31398 dihydrochlorideSummary: p53蛋白稳定剂
- A4456 Plumbagin中文名: 白花丹素Summary: 抗癌剂
- A4455 Piperlongumine中文名: 荜茇酰胺Summary: 细胞死亡诱导剂
- A3763 RG73882 CitationSummary: MDM2拮抗剂
- A3762 RG71125 CitationTarget: MDM2Summary: MDM2抑制剂
- A3671 Nutlin-3a chiral2 CitationSummary: MDM2抑制剂,抗增殖。