p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- B4677 NVP-CGM097Summary: 有效的选择性MDM2抑制剂
- A8804 AMG2322 CitationTarget: p53-MDM2 interactionSummary: p53-MDM2抑制剂
- A9903 p53/MDM2 Set ISummary: 抑制MDM2-p53相互作用
- A8567 Tenovin-3Summary: p53激活剂
- A4484 PRIMA-1METSummary: 恢复突变p53的活性,诱导BAX和PUMA
- A4482 Pifithrin-μ1 CitationTarget: Autophagy|p53|HSP70Summary: p53结合抑制剂,抗凋亡。
- A4477 Cyclic Pifithrin-α hydrobromide中文名: 环状抑制剂-α氢溴酸盐Summary: P53抑制剂
- A4487 WR 1065Summary: P53/p21waf-1/MDM2激活剂
- A4486 SJ 172550Summary: MDMX抑制剂
- A4485 RETRA hydrochlorideSummary: 抗癌剂