Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- A8165 Q-VD(OMe)-OPh6 CitationTarget: CaspasesSummary: Pan-caspase抑制剂
- A1930 Apoptosis InhibitorSummary: 与caspase-3的抑制相关
- A1925 Caspase-3/7 Inhibitor I2 CitationTarget: CaspasesSummary: Caspase-3/7抑制剂
- A1924 Z-WEHD-FMK1 CitationSummary: 强效、细胞渗透性和不可逆性的Caspase 5抑制剂
- A1923 Z-VEID-FMK2 CitationTarget: CaspasesSummary: Caspase-6抑制剂
- A1922 Z-VDVAD-FMKSummary: Caspase-2抑制剂
- A1921 Z-DQMD-FMK3 CitationTarget: CaspasesSummary: 细胞渗透性Caspase-3抑制剂
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3抑制剂
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: 广谱caspase抑制剂
- A1901 Q-VD-OPh53 CitationTarget: CaspasesSummary: Pan-caspase抑制剂。