Bcl-2 Family - Animal Experiments
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
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- A8737 S6384511 CitationTarget: MCL1Summary: MCL1抑制剂
- B6011 A-12104772 CitationTarget: Mcl-1Summary: MCL-1抑制剂
- B5978 BDA-366Target: Bcl-2Summary: BCL2 BH4 结构域的选择性拮抗剂
- B5846 Radotinib(IY-5511)中文名: 雷多替尼Target: PDGFR|Bcr-AblSummary: Bcr-Abl酪氨酸激酶抑制剂
- B4902 (+)-Apogossypol中文名: 變棉子酚,阿朴棉子酚,变棉子酚Target: Bcl-2Summary: Bcl-2家族蛋白抑制剂
- B4881 UMI-771 CitationTarget: Mcl-1Summary: Mcl-1抑制剂
- B1080 Marinopyrrole ATarget: Mcl-1Summary: 选择性Mcl-1抑制剂
- A4461 Bax inhibitor peptide V5Target: BaxSummary: Bax抑制剂
- A3196 AT-101中文名: (R)-(-)-棉子酚Target: NS3/4a ProteasesSummary: BH3-类似物,棉酚对映异构体
- A4199 Sabutoclax2 CitationTarget: Bcl-2|Mcl-1|Bfl-1Summary: Pan-Bcl-2抑制剂