K-Ras(G12C) inhibitor 6
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
K-Ras (G12C) inhibitor 6是致癌突变K-Ras G12C的变构抑制剂[1]。
K-Ras (G12C) inhibitor 6是半胱氨酸反应性的小分子，不可逆地结合GTPase K-Ras G12C突变，而非野生型K-Ras，相对效力值为4.2。K-Ras (G12C) inhibitor 6在K-Ras上的结合口袋是一个新的变构口袋，即S-IIP。该口袋的结合导致Ras相对核苷酸亲和力的变化，对GDP的亲和力高于GTP，导致无活性Ras的积累。由于K-Ras突变在人类癌症中相当普遍，K-Ras G12C的抑制剂在肿瘤细胞中具有抑制活性。据报道，在肺癌细胞系中，K-Ras G12C的某些抑制剂能有效减少细胞活力，增加细胞凋亡[1]。
参考文献：
[1] Ostrem J M, Peters U, Sos M L, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 2013, 503(7477): 548-551.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 405.34 |
| Cas No. | 2060530-16-5 |
| Formula | C17H22Cl2N2O3S |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCC1NC(=O)CCCS)C(=O)COC2=C(C=C(C=C2)Cl)Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | K-Ras(G12C) inhibitor 6是一种选择性的致癌基因K-Ras(G12C)变构抑制剂。 | |||||
| 靶点 | K-Ras(G12C) | |||||
| IC50 | ||||||
质量控制和MSDS
- 批次:
化学结构
