SB742457
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB742457是5-HT6受体的选择性拮抗剂，pKi值为9.63[1]。
SB742457是一种高选择性的5-HT6受体拮抗剂，对人的5-HT6受体具有较高亲和力，
pKi值为9.63。由于其口服生物可利用性，SB742457可以促进大鼠的脑渗透。此外，SB742457以1.5 mg/kg的剂量口服给药后可显著抑制胆碱能受体拮抗剂东莨菪碱（0.5 mg/kg）诱导的新物体识别任务中的认知缺陷。除此之外，急性口服SB742457可以显著增加大鼠内侧前额叶皮质的胞外谷氨酸和乙酰胆碱水平[1]。
参考文献：
[1] Aaron T.T. Chuang, Andrew Foley, Perdita L. Pugh, David Sunter, Xin Tong, Ciaran Regan, Lee A. Dawson, Andrew D. Medhurst, Neil Upton.5-HT6 receptor antagonist SB-742457 as a novel cognitive enhancing agent for Alzheimer’s disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 2, Issue 3, Supplement, Pages?S631–S632, July 2006?
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 353.44 |
| Cas No. | 607742-69-8 |
| Formula | C19H19N3O2S |
| Solubility | insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 3-(benzenesulfonyl)-8-piperazin-1-ylquinoline |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | SB742457是5-HT6受体的高选择性拮抗剂，pKi值为9.63。 | |||||
| 靶点 | 5-HT6 | |||||
| IC50 | 9.63(pKi) | |||||
质量控制和MSDS
- 批次:
化学结构
