Rosiglitazone maleate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Rosiglitazone maleate是rosiglitazone的马来酸盐，是一种有效的胰岛素敏化剂，可用于治疗糖尿病。Rosiglitazone属于噻唑烷二酮（TZD），可选择性结合细胞核转录因子过氧化物酶体增殖体激活的受体γ（PPARγ）。作为一种TZD，rosiglitazone可通过激活PPARγ，提高终端器官对胰岛素的敏感度，使之降低血糖浓度。除了针对胰岛素抗性的有益效果外，近期研究表明，rosiglitazone与多种中度到严重的不利事件有关，包括血液稀释、贫血、增重、水肿以及更高的心脏衰竭风险和心肌缺血事件。
参考文献：
Andreas Pfutzner, Birgit Wilhelm, and Thomas Forst. Rosiglitazone and glimeperide: review of clinical results supporting a fixed dose conbination. Vascular Health and Risk Management 2007: 3(2) 211-220
Adie Vilioen and Alan Sinclair. Safety and efficacy of rosiglitazone in the elderly diabetic patient. Vascular Health and Risk Management 2009:5 389-395
| Storage | Store at -20°C |
| M.Wt | 473.5 |
| Cas No. | 155141-29-0 |
| Formula | C18H19N3O3S·C4H4O4 |
| Synonyms | Avandia,Avandaryl,BRL 49653C,BRL-49653C |
| Solubility | ≥23.7 mg/mL in DMSO; insoluble in H2O; ≥19 mg/mL in EtOH with ultrasonic |
| Chemical Name | (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
