SCH900776 S-isomer
Catalog No.
A3806
检查点激酶（Chk）抑制剂
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SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). SCH900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest and enhances cytarabine cytotoxicity in acute leukemia cell lines and leukemic blasts in vitro.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 376.25 |
| Cas No. | 891494-64-7 |
| Formula | C15H18BrN7 |
| Synonyms | SCH 900776 S-isomer;SCH-900776 S-isomer |
| Solubility | ≥37.6 mg/mL in DMSO; insoluble in H2O; ≥47.8 mg/mL in EtOH with ultrasonic |
| Chemical Name | (S)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine |
| SDF | Download SDF |
| Canonical SMILES | NC1=C(Br)C([C@@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
