SB269970 HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB269970 HCl是一种有效的和选择性的5-HT7受体拮抗剂，pKi值为8.3[1]。
SB269970是5-HT7受体的选择性拮抗剂。相较于其他的受体和酶，它对5-HT7受体至少有100倍以上的选择性。SB269970阻止5-CT与H293细胞中h5-HT7(a)以及豚鼠大脑皮层细胞膜上表达的人克隆5-HT7受体的结合，pKi值分别为8.9和8.3。在5-HT 7（a）/ HEK293的细胞膜（pA 2为8.5）和豚鼠海马（PKB为8.3）中，SB269970抑制5-CT刺激的腺苷酸环化酶的活性。在豚鼠中，SB269970几乎完全抑制5-CT诱导的低体温症，ED50值为2.96 mg/ kg [1]。
参考文献：
[1] Hagan J J, Price G W, Jeffrey P, et al. Characterization of SB-269970-A, a selective 5-HT7 receptor antagonist. British journal of pharmacology, 2000, 130(3): 539-548.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 388.95 |
| Cas No. | 261901-57-9 |
| Formula | C18H29ClN2O3S |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | SB269970 HCl是5-HT7受体的拮抗剂，pKi值为8.3。 | |||||
| 靶点 | 5-HT7 | |||||
| IC50 | 8.3(pKi) | |||||
化学结构
