SB-334867 free base
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB-334867游离碱是orexin-1受体的选择性拮抗剂[1].
Orexin-A和orexin-B是大鼠下丘脑分离出的两种多肽.二者参与一些生理功能,例如控制饲喂\能量代谢和调节睡眠 - 觉醒周期.
SB-334867游离碱能抑制CHO-OX1细胞中orexin-A和orexin-B诱导的钙应答,pKB值分别为7.27和7.23.SB-334867对OX1受体的选择性高于OX2受体.CHO-OX2细胞中,其能分别抑制32.7%和22%的orexin-A和orexin-B诱导的钙应答.而且,SB-334867能够降低orexin-A诱导的和禁食诱导的食物摄取.SB-334867的急性厌食效应与所有活跃行为的显著降低相关[1, 2].
参考文献:
[1] Smart D, Sabido-David C, Brough S J, et al. SB-334867-A: the first selective orexin-1 receptor antagonist. British journal of pharmacology, 2001, 132(6): 1179-1182.
[2] Rodgers R J, Halford J C G, Nunes de Souza R L, et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. European Journal of Neuroscience, 2001, 13(7): 1444-1452.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 319.32 |
Cas No. | 792173-99-0 |
Formula | C17H13N5O2 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO |
Chemical Name | 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea |
SDF | Download SDF |
Canonical SMILES | CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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