SB-222200
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
SB 222200是一种有效的和选择性的NK-3受体拮抗剂[1]。
神经激肽3（NK-3）受体是G蛋白偶联受体超家族的成员，作为速激肽的受体而起作用。激活的NK-3受体通过激活磷脂酶C，引起磷酸肌醇4,5二磷酸（PIP2）分解成1,4,5三磷酸肌醇（IP3）和二酰基甘油[1]。
在表达hNK-3受体的中国仓鼠卵巢（CHO）细胞中，SB 222200抑制神经激肽B（NKB）与细胞膜的结合，Ki值为4.4 nM。在表达hNK-3受体的HEK 293细胞中，SB 222200拮抗NKB诱导的Ca2+动员，IC50值为18.4 nM[1]。
在小鼠模型中，SB-222200剂量依赖性地抑制senktide（NK-3受体的选择性激动剂）诱导的行为反应（快速摇头和尾鞭），ED50值为5 mg/kg，该抑制效应与SB-222200在脑内的浓度显著相关[1]。用SB 222200处理成年雄性CD-1小鼠，当用可卡因挑战时，小鼠具有显著增强的多动行为，表明NK-3受体的阻断增强多巴胺介导的多动行为[2]。
参考文献：
[1]. Sarau HM, Griswold DE, Bush B, et al. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther, 2000, 295(1): 373-381.
[2]. Nwaneshiudu CA, Unterwald EM. Blockade of neurokinin-3 receptors modulates dopamine-mediated behavioral hyperactivity. Neuropharmacology, 2009, 57(3): 295-301.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 380.48 |
| Cas No. | 174635-69-9 |
| Formula | C26H24N2O |
| Synonyms | SB 222200;SB222200 |
| Solubility | insoluble in H2O; ≥19.02 mg/mL in DMSO; ≥43.6 mg/mL in EtOH |
| Chemical Name | 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
