切换导航
关闭
  • 菜单
  • Setting

Sandramycin

山卓霉素
Catalog No.
C4235
环肽抗生素
组合的产品项目
规格价格库存 数量
1mg
¥ 5,416.00
Ship with 10-15 days
5mg
¥ 18,037.00
Ship with 10-15 days

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

Sandramycin is a cyclic depsipeptide antibiotic that was first isolated from cultured broth of a Nocardioides sp [1].

Sandramycin is an antitumor antibiotic. Sandramycin was closely related to the cyclic depsipeptides luzopeptins A, B, C and D. Sandramycin exhibited strong inhibition to the Gram-positive organisms Bacillus subtilis, Staphylococcus aureus and Streptococcusfaecalis. Its antimicrobial activity paralleled that which was observed for echinomycin and luzopeptin A [1]. Sandramycin was also a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules [2].

In transplantable mouse leukemia P388, Sandramycin was moderately active with values comparable to those for luzopeptin A. Injection of 2 mg/kg showed the best increase in life span over the controls (61%) [1].

References:
[1].  Matson JA, Bush JA. Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties. J Antibiot (Tokyo). 1989 Dec;42(12):1763-7.
[2].  Boger DL, Saionz KW. DNA binding properties of key sandramycin analogues: systematic examination of the intercalation chromophore. Bioorg Med Chem. 1999 Feb;7(2):315-21.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1221.3
Cas No.100940-65-6
FormulaC60H76N12O16
Synonyms(-)-Sandramycin
SolubilitySoluble in DMSO
Chemical NameN-[(3-hydroxy-2-quinolinyl)carbonyl]-D-seryl-(2S)-2-piperidinecarbonylglycyl-N-methylglycyl-N-methyl-L-valine, bimol. (5→1'3),(5'→13)-dilactone
SDFDownload SDF
Canonical SMILESO=C([C@@H](COC([C@@H](N(C(CN(C(CNC([C@@](CCCC1)([H])N1C2=O)=O)=O)C)=O)C)C(C)C)=O)NC(C3=NC(C=CC=C4)=C4C=C3O)=O)N(CCCC5)[C@]5([H])C(NCC(N(CC(N([C@H](C(OC[C@H]2NC(C6=NC(C=CC=C7)=C7C=C6O)=O)=O)C(C)C)C)=O)C)=O)=O
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

Sandramycin