Resveratrol
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
- 1. Xin Chou, Xiaohu Li, et al. "Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation." Ecotoxicol Environ Saf. 2022 Oct 15;245:114098. PMID: 36137422
- 2. Li Y, Xi Y, et al. "Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway." Int Immunopharmacol. 2020;83:106386. PMID: 32193100
- 3. Song Y, Chen Y, et al. "Resveratrol Suppresses Epithelial-Mesenchymal Transition in GBM by Regulating Smad-Dependent Signaling." Biomed Res Int. 2019 Apr 7;2019:1321973. PMID: 31119150
- 4. Chou X, Ding F, et al. "Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells." Arch Toxicol. 2019 Feb 22. PMID: 30796460
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 228.24 |
Cas No. | 501-36-0 |
Formula | C14H12O3 |
Solubility | insoluble in H2O; ≥48.2 mg/mL in EtOH with ultrasonic; ≥9.65 mg/mL in DMSO |
Chemical Name | 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol |
SDF | Download SDF |
Canonical SMILES | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验[1]: | |
细胞系 |
原代神经元培养物; 神经母细胞瘤SH-SY5Y细胞系 |
溶解方法 |
在DMSO中的溶解度 >9.7 mg/mL。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
0.1, 1和10 μM; 50 μM |
应用 |
在原代神经元培养物中,resveratrol(0.1,1和10 μM)抑制OGD/再灌注诱导的细胞凋亡,并以浓度依赖性方式抑制caspase-3和caspase-12 mRNA的过表达。在神经母细胞瘤SH-SY5Y细胞系中,resveratrol(50 μM)通过改善细胞内氧化应激并增加促存活基因Bcl-2的活性来抑制过量多巴胺诱导的细胞死亡。 |
动物实验[2]: | |
动物模型 |
经历心肌缺血的大鼠 |
剂量 |
2.5, 5.0, 25或50 mg/kg; 14天,灌胃给药 |
应用 |
在经受心肌缺血的大鼠中,resveratrol(2.5和5.0 mg/kg)通过改善缺血后心室恢复显示出心脏保护作用,并减少心肌梗死面积和心肌细胞凋亡。 然而,25或50 mg / kg剂量的resveratrol可抑制心脏功能,增加心肌梗死面积和凋亡细胞数量。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Nilendra Singh, Megha Agrawal, and Sylvain Doré. Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models. ACS Chem Neurosci. 2013 Aug 21; 4(8): 1151–1162. [2]. Dudley J1, Das S, Mukherjee S, et al. Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose. J Nutr Biochem. 2009 Jun;20(6):443-52. |
质量控制和MSDS
- 批次: