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HIV Integrase

Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

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生化试剂

  1. 产品编号 产品名称 信息
  2. A4069 BMS-707035 HIV-1整合酶抑制剂
  3. A4072 MK-2048 第二代HIV-1整合酶抑制剂
  4. C4787 Equisetin HIV-1整合酶抑制剂
  5. B5856 GSK1349572 sodiuM salt 下一代HIV整合酶(IN)抑制剂
  6. B4851 (±)-BI-D 整合酶抑制剂
  7. B4845 BI 224436 新型HIV-1非催化位点整合酶抑制剂
  8. A8566 GSK744 (S/GSK1265744) HIV整合酶抑制剂
  9. A4070 Elvitegravir (GS-9137) HIV-1整合酶抑制剂
  10. A4071 Fluorouracil (Adrucil) 胸苷酸合成酶抑制剂,抗肿瘤药物。
  11. A4073 Raltegravir (MK-0518) HIV-1整合酶抑制剂
  12. A4074 S/GSK1349572 HIV整合酶抑制剂
  13. A3461 HIV-1 integrase inhibitor 用于抗HIV
  14. A3653 Nelfinavir Mesylate HIV蛋白酶抑制剂,治疗HIV的抗逆转录病毒药物
  15. B1122 Nelfinavir HIV-1蛋白酶抑制剂