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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

生化试剂

  1. 产品编号 产品名称 信息
  2. A3002 ABT-888 (Veliparib) Top Seller PARP抑制剂
  3. A1877 XAV-939 Top Seller Tankyrase 1/2抑制剂
  4. A4164 AZD2461 PARP抑制剂
  5. A4159 PJ34 hydrochloride Top Seller 有效的细胞渗透性PARP抑制剂
  6. A4158 AG-14361 PARP1抑制剂
  7. A4157 Iniparib (BSI-201) PARP1抑制剂
  8. A4156 Rucaparib (AG-014699,PF-01367338) Top Seller 有效的PARP 抑制剂
  9. A4154 Olaparib (AZD2281, Ku-0059436) Top Seller PARP1/PARP2抑制剂
  10. A4153 BMN 673 Top Seller PARP抑制剂
  11. A8893 Rucaparib (free base) PARP抑制剂
  12. A8808 ME0328 PARP抑制剂
  13. A8601 Tankyrase Inhibitors (TNKS) 49 端锚聚合酶抑制剂
  14. A8600 Tankyrase Inhibitors (TNKS) 22 端锚聚合酶抑制剂
  15. A4529 JW 55 Top Seller PARP结构域抑制剂
  16. A3729 PJ34 PARP-1抑制剂
  17. A4161 INO-1001 强效的PARP抑制剂
  18. A4531 WIKI4 Wnt/β-Catenin信号传导和tankyrase抑制剂
  19. A4530 NU 1025 PARP抑制剂
  20. A4527 DR 2313 PARP抑制剂
  21. A4526 BYK 49187 PARP-1/PARP-2的强效抑制剂
  22. A4525 BYK 204165 PARP-1的有效选择性抑制剂
  23. A3617 MK-4827 PARP-1/-2抑制剂
  24. A3246 BMN-673 8R,9S PARP抑制剂
  25. A4163 UPF 1069 PARP2选择性抑制剂
  26. A4160 A-966492 PARP-1/-2抑制剂
  27. A4524 4-HQN PARP抑制剂
  28. A4528 EB 47 PARP-1抑制剂
  29. B1163 MK-4827 hydrochloride PARP1/PARP2抑制剂
  30. B1164 MK-4827 tosylate PARP1/PARP2抑制剂
  31. B3393 MK-4827 Racemate PARP1/PARP2的选择性抑制剂
  32. A3958 Veliparib dihydrochloride PARP-1/PARP-2抑制剂