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IAP

Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).

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生化试剂

  1. 产品编号 产品名称 信息
  2. A3891 Triptolide IL-2/MMP-3/MMP7/MMP19抑制剂
  3. A4219 Birinapant (TL32711) XIAP/cIAP1拮抗剂
  4. A4221 YM155 Survivin抑制剂,细胞凋亡抑制剂
  5. A8235 Embelin 细胞通透的XIAP抑制剂
  6. A8815 SM-164 抗癌药
  7. A4224 GDC-0152 IAP 拮抗剂
  8. A3541 LCL161 IAPs拮抗剂
  9. B4653 BV6 IAP蛋白抑制剂