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Bcl-xL

BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

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生化试剂

  1. 产品编号 产品名称 信息
  2. A8168 HA14-1 Top Seller 有效的、细胞通透的Bcl-2抑制剂
  3. A8193 ABT-737 Top Seller Bcl-2抑制剂
  4. A4234 TW-37 Top Seller Bcl-2抑制剂,抑制Bcl-2、Bcl-XL和Mcl-1。
  5. A8634 WEHI-539 hydrochloride Bcl-xL抑制剂
  6. A3424 Gambogic Acid Caspase激活剂和凋亡诱导剂
  7. A3935 WEHI-539 选择性的Bcl-xL抑制剂
  8. B6163 A-1155463 BCL-XL抑制剂
  9. B6164 A-1331852 BCL-XL抑制剂