Raloxifene HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Raloxifene HCl(LY139481)是一种有效的和选择性的雌激素受体(ER)调节剂,IC50值为2.9~5.7 nM[1].
Raloxifene HCl(LY139481)是一种选择性的和非竞争性的雌激素受体(ER)调节剂,对人类肝脏胞液中酞嗪氧化酶的IC50值为2.9~5.7 nM.此外,Raloxifene是一种有效的三种氧化反应的抑制剂,即酞嗪氧化\香草醛氧化和尼古丁-△-1’(5’)-亚胺离子氧化,Ki值分别为0.87 nM\1.2 nM和1.4 nM.Raloxifene HCl的抑制能力无时间依赖特征.除此之外,Raloxifene HCl可非竞争性地抑制醛脱氢酶催化的还原反应,Ki值为52 nM[1].
参考文献:
[1] Obach RS. Potent inhibition of human liver aldehyde oxidase by raloxifene. Drug Metab Dispos. 2004 Jan;32(1):89-97.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 510.04 |
Cas No. | 82640-04-8 |
Formula | C28H28ClNO4S |
Solubility | ≥22.35 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone;hydrochloride |
SDF | Download SDF |
Canonical SMILES | C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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