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(R)-(+)-Etomoxir sodium salt

乙莫克舍(钠盐)
Catalog No.
B7679
肉碱棕榈酰转移酶I(CPT1)抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 763.00
现货
10mg
¥ 1,100.00
现货
50mg
¥ 3,963.00
现货

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A

背景

(R)-(+)-Etomoxir sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1(CPT-1)[1].

Etomoxir (100 μM) has no effect on T cells cultured in high glucose. In contrast, there is a significant increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions[2].

C57BL/6 mice treated with Etomoxir (15 mg/kg, i.p) reduce the infiltration of immune cells in the central nervous system. Only a small number of macrophages, activated microglia or T cells are present, while reducing the inflammatory response and Demyelinating reaction[2].

References:

[1]. Rupp H, Zarain-Herzberg A, Maisch B. The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure. Herz, 2002, 27(7): 621-636.

[2]. Shriver L P, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1.

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt320.74
Cas No.828934-41-4
FormulaC15H18ClNaO4
Solubilityinsoluble in H2O; insoluble in EtOH; ≥12 mg/mL in DMSO
Chemical Namesodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate
SDFDownload SDF
Canonical SMILESClC1=CC=C(C=C1)OCCCCCC[C@@]2(C([O-])=O)OC2.[Na+]
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试验操作

Cell experiment:[1]

Cell lines

Splenocytes isolated from C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG35-55) peptide

Reaction Conditions

100 μM etomoxir for 72 h incubation

Applications

Etomoxir exhibited no effect on MOG35-55-specific T cells cultured in high glucose conditions in terms of pro-inflammatory cyokine production and apoptosis. In contrast, there were a significant reduction in IFN-γ production and a substantial increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions.

Animal experiment:[1]

Animal models

A mouse model of multiple sclerosis

Dosage form

15 mg/kg

Injected intraperitoneally on days 8 and 15 after experimental autoimmune encephalomyelitis (EAE) induction

Applications

Etomoxir-treated mice displayed a reduced immune cell infiltration in the central nervous system with few macrophages, activated microglia, or T cells present. Etomoxir treatment also alleviated inflammation and prevented myelin destruction in spinal cords.

Note

The technical data provided above is for reference only.

References:

1. Shriver LP, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1: 79.

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