(R)-(+)-Etomoxir sodium salt
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
(R)-(+)-Etomoxir sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1(CPT-1)[1].
Etomoxir (100 μM) has no effect on T cells cultured in high glucose. In contrast, there is a significant increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions[2].
C57BL/6 mice treated with Etomoxir (15 mg/kg, i.p) reduce the infiltration of immune cells in the central nervous system. Only a small number of macrophages, activated microglia or T cells are present, while reducing the inflammatory response and Demyelinating reaction[2].
References:
[1]. Rupp H, Zarain-Herzberg A, Maisch B. The Use of Partial Fatty Acid Oxidation Inhibitors for Metabolic Therapy of Angina Pectoris and Heart Failure. Herz, 2002, 27(7): 621-636.
[2]. Shriver L P, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 320.74 |
Cas No. | 828934-41-4 |
Formula | C15H18ClNaO4 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥12 mg/mL in DMSO |
Chemical Name | sodium (R)-2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylate |
SDF | Download SDF |
Canonical SMILES | ClC1=CC=C(C=C1)OCCCCCC[C@@]2(C([O-])=O)OC2.[Na+] |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Cell experiment:[1] | |
Cell lines |
Splenocytes isolated from C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein (MOG35-55) peptide |
Reaction Conditions |
100 μM etomoxir for 72 h incubation |
Applications |
Etomoxir exhibited no effect on MOG35-55-specific T cells cultured in high glucose conditions in terms of pro-inflammatory cyokine production and apoptosis. In contrast, there were a significant reduction in IFN-γ production and a substantial increase in apoptosis in etomoxir-treated cultures stimulated with antigen under low glucose conditions. |
Animal experiment:[1] | |
Animal models |
A mouse model of multiple sclerosis |
Dosage form |
15 mg/kg Injected intraperitoneally on days 8 and 15 after experimental autoimmune encephalomyelitis (EAE) induction |
Applications |
Etomoxir-treated mice displayed a reduced immune cell infiltration in the central nervous system with few macrophages, activated microglia, or T cells present. Etomoxir treatment also alleviated inflammation and prevented myelin destruction in spinal cords. |
Note |
The technical data provided above is for reference only. |
References: 1. Shriver LP, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Scientific Reports, 2011, 1: 79. |
质量控制和MSDS
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