PSN632408
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PSN632408是一种新型选择性的人类和小鼠GPR119小分子激动剂,EC50值分别为5.6±0.99 μM和7.9±0.7 μM [1].
酵母荧光实验表明,PSN632408 激活人类和小鼠GPR119,EC50值分别为5.6±0.99 μM和7.9±0.7 μM[1].在HEK-OSGPR116细胞中,PSN632408能够以剂量依赖的方式提高cAMP水平,EC50值为1.9±0.14 μM.体内试验中,PSN632408以剂量依赖的方式诱导大鼠饲喂模型中食物摄入减少和急性厌食效应[1].
参考文献：
[1]. Overton HA1, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C.Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006 Mar;3(3):167-75
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 360.41 |
| Cas No. | 857652-30-3 |
| Formula | C18H24N4O4 |
| Solubility | Soluble in DMSO |
| SDF | Download SDF |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
