Pregnenolone
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
神经甾体是内源性分子,在人类大脑中十分丰富.在啮齿动物模型中,多种神经甾体都有重要且广泛的功能,在生理学相关的浓度下对大脑功能起到关键作用.孕烯醇酮(Pregnenolone,3β-羟基孕甾-5-烯-20-酮),也称作P5,是一种内源性甾体激素.
在体外:孕烯醇酮是一种前体,几乎所有的其他甾体激素都从其而来,包括DHEA\睾酮\孕酮\雌激素和皮质醇.孕烯醇酮也是大脑中的一种强有力的神经甾体,调控神经元到神经元的信息传输,并强效地影响学习和记忆过程[1].
在体内:孕烯醇酮的硫酸盐衍生物(PREGS)调控年龄诱导的学习能力衰退的功能在16月龄的被动回避的降压型小鼠中进行了研究.相对于3月龄小鼠,16月龄小鼠的被动回避任务中出现了降压延迟下降,表明老龄小鼠记忆力衰退.在该测试前给老龄小鼠注射PREGS则可剂量依赖地改善24 h的记忆延迟现象.
临床试验:人体研究发现低PREGS水平个体使用PREG后可改善学习和记忆功能紊乱,但其他研究没有发现PREG使用后有显著的认知效果[1].
参考文献：
[1] Vallée M, Mayo W, Le Moal M. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res Brain Res Rev. 2001 Nov;37(1-3):301-12.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 316.48 |
| Cas No. | 145-13-1 |
| Formula | C21H32O2 |
| Solubility | insoluble in H2O; ≥15.82 mg/mL in DMSO with gentle warming; ≥2.42 mg/mL in EtOH with ultrasonic |
| Chemical Name | 1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1CC2=CC[C@H]3[C@H]4[C@]([C@@H](C(C)=O)CC4)(C)CC[C@H]3[C@@]2(C)CC1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
