PNU-120596
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
PNU-120596是一种α7神经元烟碱型乙酰胆碱受体(nAChR)的正向变构调节剂[1].
PNU-120596是一种2型PAM.在基于细胞的试验中,PNU-120596在3 μM浓度下可显著增强Ca2+介导的信号.该物质可增强Ach诱发的Ca2+流,在SH-EP1细胞中EC50值为216 nM.PNU-120596也可在爪蟾卵母细胞中明显提高激动剂诱发的电流和电流持续时间.相比其他神经元烟碱型乙酰胆碱受体,PNU-120596对α7nAChR具有特异性.PNU-120596也可在大鼠海马中间神经元中加强α7nAChRs介导的ACh反应.PNU-120596通过增强ACh对GABA能中间神经元的兴奋性效应,可调节ACh依赖的增加.此外,PNU-120596可提高CREB的磷酸化,改善啮齿动物识别记忆模型的表现[1,2].
参考文献:
[1] Hurst R S, Hajós M, Raggenbass M, et al. A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. The Journal of neuroscience, 2005, 25(17): 4396-4405.
[2] Bertrand D, Gopalakrishnan M. Allosteric modulation of nicotinic acetylcholine receptors. Biochemical pharmacology, 2007, 74(8): 1155-1163.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 311.73 |
Cas No. | 501925-31-1 |
Formula | C13H14ClN3O4 |
Solubility | ≥31.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
Chemical Name | 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea |
SDF | Download SDF |
Canonical SMILES | CC1=CC(=NO1)NC(=O)NC2=CC(=C(C=C2OC)OC)Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | PNU-120596是一种α7 nAChR的正向变构调节剂,EC50值为216 nM. | |||||
靶点 | α7 nAChR | |||||
IC50 | 216 nM(EC50) |
质量控制和MSDS
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