PK 44 phosphate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC 50：15.8 nM（DPP-IV）
DPP-IV是由DPP4基因编码的蛋白质，是大多数细胞类型的细胞膜上表达的抗原性酶，参与免疫调节、信号转导和细胞凋亡。二肽基肽4又称为DPP-4或gliptins，其抑制剂是一类阻断DPP-4的口服降糖药，可用于治疗2型糖尿病。PK 44 phosphate是二肽基肽酶IV（DPP-IV）的有效抑制剂。
体外实验：作为DPP-IV的强效抑制剂，与DPP-8和DPP-9相比，PK44 phosphate对DPP-IV具有超过1000倍的选择性[1]。
在体实验：在小鼠口服葡萄糖耐受性测定实验中，PK 44 phosphate能够提高葡萄糖耐受性[1]。
临床试验：PK 44 phosphate目前处于临床前开发阶段，没有正在进行的临床试验。
参考文献：
[1] Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 527.34 |
| Cas No. | 1017682-65-3 |
| Formula | C17H16F5N7O·H3PO4 |
| Solubility | <52.73mg/ml in H2O; <52.73mg/ml in DMSO |
| Chemical Name | (R)-3-amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one phosphate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=NNC4=C3C=CC(F)=C4F.O=P(O)(O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | PK 44 phosphate是二肽基肽酶IV（DPP-IV）的有效抑制剂，IC50值为15.8 nM。 | |||||
| 靶点 | DPP-IV | |||||
| IC50 | 15.8 nM | |||||
化学结构
