Piperlongumine
荜茇酰胺
Catalog No.
A4455
细胞死亡诱导剂
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Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
- 1. Di Chen, Xinyue Wei, et al. "Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway." J Int Med Res. 2022 Apr;50(4):3000605221093308. PMID: 35481419
- 2. Chen D, Ma Y, et al. "Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation." Molecules. 2020;25(1):216. PMID: 31948057
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 317.34 |
Cas No. | 20069-09-4 |
Formula | C17H19NO5 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥10.45 mg/mL in DMSO |
Chemical Name | 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one |
SDF | Download SDF |
Canonical SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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