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Pioglitazone HCl

现货
Catalog No.
A4324
PPARγ激动剂
组合的产品项目
规格价格库存 数量
500mg
¥ 1,520.00
现货
100mg
¥ 580.00
现货
10mM (in 1mL DMSO)
¥ 500.00
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Background

Pioglitazone HCl is a potent and highly selective agonist of PPARγ with IC50 value of 3μM[1].

Pioglitazone HCl can increase both insulin-stimulated glucose uptake in peripheral tissues and insulin sensitivity in hepatic and adipose tissue. It is treated for hyperglycemia and Type 2 diabetes (T2D). Pioglitazone needs insulin as a co-factor for PPAR agonism so it is not effect when being treated to late stages of T2D with developed insulinopenia. In clinical trials, 15mg pioglitazone produces significant improvements in HbA1c and fasting plasma glucose (FPG) [2].

Pioglitazone is also reported to have multiple beneficial effects on lipid metabolism. It produces significant decreases in TG and significant increases in high density lipoprotein (HDL) in clinical studies [2].

References:
[1] Saad S, Agapiou DJ, Chen XM, Stevens V, Pollock CA. The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrol Dial Transplant. 2009 Apr;24(4):1130-41.
[2] Dorkhan M, Frid A. A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes. Vasc Health Risk Manag. 2007;3(5):721-31.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt392.9
Cas No.112529-15-4
FormulaC19H20N2O3S.HCl
Solubility≥19.65 mg/mL in DMSO, ≥7.52 mg/mL in EtOH with ultrasonic and warming, <2.49 mg/mL in H2O
Chemical Name5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
SDFDownload SDF
Canonical SMILESCCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

化学结构

Pioglitazone HCl