Pioglitazone HCl
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Pioglitazone HCl是PPARγ的强效高选择性激动剂,IC50值为3 μM[1]。
Pioglitazone HCl可以增加外周组织中胰岛素刺激的葡萄糖吸收以及肝和脂肪组织中胰岛素的敏感性。Pioglitazone HCl被用于治疗高血糖症和2型糖尿病(T2D)。Pioglitazone 需要胰岛素作为辅因子激活PPAR,对胰岛素缺乏的T2D晚期患者没有治疗效果。在临床试验中,15 mg的Pioglitazone显著改善了糖化血红蛋白(HbA1c)和空腹血糖(FPG)[2]。
Pioglitazone对脂质代谢产生多种有益作用,在临床研究中,它显著减少TG的含量,增加高密度脂蛋白(HDL)含量[2]。
参考文献:
[1] Saad S, Agapiou DJ, Chen XM, Stevens V, Pollock CA. The role of Sgk-1 in the upregulation of transport proteins by PPAR-{gamma} agonists in human proximal tubule cells. Nephrol Dial Transplant. 2009 Apr;24(4):1130-41.
[2] Dorkhan M, Frid A. A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes. Vasc Health Risk Manag. 2007;3(5):721-31.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 392.9 |
Cas No. | 112529-15-4 |
Formula | C19H20N2O3S·HCl |
Solubility | insoluble in H2O; ≥19.65 mg/mL in DMSO; ≥7.52 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride |
SDF | Download SDF |
Canonical SMILES | CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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