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Pertussis Toxin

现货
Catalog No.
B7273
引起百日咳
组合的产品项目
规格价格库存 数量
50ug
¥ 3,640.00
Ship with 10-15 days

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Background

Protein-based AB5-type exotoxin Pertussis toxin (PT) is produced by the bacterium Bordetella pertussis. PT can cause whooping cough.

In vitro: PT has the effect on innate immune response. The effects of PT on human monocyte-derived DC (MDDC), including maturation, are regulated by cAMP [1].

In vivo: Pertussis toxin did not affect the relaxation and contraction properties of isolated NIH or BALB/c mouse trachea, but significantly declined KCl or noradrenaline-induced maximal contraction and decreased sensitivity to noradrenaline in isolated male Wistar rat small mesenteric resistance arteries [2].

Clinical trial: Pertussis toxin was used as vaccine, acellular pertussis booster immunizations, to young and older persons in order to reduce the community transmission and to enhance the protection. Older persons with infections are mainly asymptomatic. Acellular pertussis boosters provide protection against symptomatic pertussis and give protection against mild and asymptomatic infections. The use of boosters may reduce transmission rate, especially in infant population [3].

References:
[1] Bagley KC, Abdelwahab SF, Tuskan RG, Fouts TR, Lewis GK.  Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway. J Leukoc Biol. 2002 Nov;72(5):962-9.
[2] van Meijeren CE, Vleeming W, van de Kuil T, Manni J, Kegler D, Hendriksen CF, de Wildt DJ.  In vivo pertussis toxin treatment reduces contraction of rat resistance arteries but not that of mouse trachea. Eur J Pharmacol. 2004 Mar 19;488(1-3):127-35.
[3] Ward JI, Cherry JD, Chang SJ, Partridge S, Keitel W, Edwards K, Lee M, Treanor J, Greenberg DP, Barenkamp S, Bernstein DI, Edelman R; APERT Study Group.  Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT). Clin Infect Dis. 2006 Jul 15;43(2):151-7. Epub 2006 Jun 5.

Chemical Properties

Physical AppearanceEach vial, when reconstituted to 500 μl with water, contains 50 μg of pertussis toxin in 0.01 M sodium phosphate, 0.05 M sodium chloride, pH 7.0
Storage2-8°C (as supplied), handle gently; do not vortex; do not freeze
M.Wt1724.44
Cas No.70323-44-3
FormulaC87H162N14O16S2
SolubilitySoluble in H2O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

Pertussis Toxin