Parathyroid hormone (1-34) (human)
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Parathyroid hormone (1-34) (human),(C181H291N55O51S2),是序列为H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH的多肽,分子量为4117.72.甲状旁腺激素(PTH)是由甲状旁腺主细胞分泌的含有84个氨基酸的多肽.它的作用是增加血液中钙离子(Ca2+)的浓度,而降钙素(由甲状腺的滤泡旁细胞(C细胞)产生的激素)的作用是降低钙离子浓度.PTH通过作用于甲状旁腺激素受体1和甲状旁腺激素受体2来增加血液中钙离子的浓度(1).甲状旁腺激素可以提高骨骼大型储存库中的钙离子释放,调节血清钙(2).它促进钙\镁离子经远端小管和髓袢升支粗段的主动重吸收(3).它通过增加活性维生素D的生成来促进肠道中钙离子的吸收.
参考文献:
1.Bieglmayer C, Prager G, Niederle B (October 2002). "Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy". Clin. Chem. 48 (10): 1731–8.
2.PooleK, Reeve J (2005). "Parathyroid hormone - a bone anabolic and catabolic agent". Curr Opin Pharmacol 5 (6): 612–7.
3.Coetzee M, Kruger MC (May 2004). "Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?". South. Med. J. 97 (5): 506–11.
- 1. Ziyue Qin, Shu Hua, et al. "Parathyroid hormone promotes the osteogenesis of lipopolysaccharide-induced human bone marrow mesenchymal stem cells through the JNK MAPK pathway." Biosci Rep. 2021 Aug 27;41(8):BSR20210420. PMID: 34350461
- 2. Zhiyuan Zou, Le Wang, et al. "Simultaneous incorporation of PTH (1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration." Bioact Mater. 2020 Dec 7;6(6):1839-1851. PMID: 33336115
- 3. Yuli Wang, Lintong Huang, et al. "Parathyroid hormone ameliorates osteogenesis of human bone marrow mesenchymal stem cells against glucolipotoxicity through p38 MAPK signaling." IUBMB Life. 2021 Jan;73(1):213-222. PMID: 33249758
- 4. Ge X, Li Z, et al. "Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways." J Cell Physiol. 2020 Feb;235(2):1209-1221. PMID: 31276209
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 4117.75 |
| Cas No. | 52232-67-4 |
| Formula | C181H291N55O51S2 |
| Synonyms | Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe |
| Solubility | ≥399.3 mg/mL in DMSO; insoluble in EtOH; ≥19.88 mg/mL in H2O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
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Cell lines |
Human kidney 293 cells stably transfected with the human parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor |
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Reaction Conditions |
0 ~ 1000 nM |
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Applications |
PTH (1-34) bound to the PTH/PTHrP receptor with an IC50 value of 2 nM. Moreover, PTH (1-34) stimulated inositol phosphate synthesis (≥ 24 nM) and cAMP production (IC50 = 0.22 nM) in 293 cells stably transfected with the PTH/PTHrP receptor. |
| Animal experiment:[1] | |
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Animal models |
Male Fisher 344 rats, 4 weeks old |
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Dosage form |
10 or 40 μg/kg/day Once daily by subcutaneous route for 1, 2, or 4 weeks |
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Applications |
Trabecular and cortical bone mass showed a dose- and time-dependent increase in the treated animals compared with the controls. These increases were evident as early as 1 week after initiation of dosing. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Frolik CA, Cain RL, Sato M, et al. Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats. Journal of Bone and Mineral Research, 1999, 14(2): 163-172. |
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质量控制和MSDS
- 批次:
化学结构
相关生物数据
相关生物数据
![parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]](/pub/media/prod_images/a/1/a1084.png)
