Palifosfamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Palifosfamide是异环磷酰胺(IFA)的活性部分[1]。
IFA是烷化剂,在各种儿科肉瘤中发挥活性,如横纹肌肉瘤(RMS)、尤因氏肉瘤(ES)、骨肉瘤(OS)和其它未分化软组织肉瘤[1]。
在人类OS细胞系SAOS-2、OS229和OS230中,Palifosfamide lysine具有广泛的活性,IC50从2.25到6.75 μM。但在OS222中IC50为31.5 μM[1]。
在CB17雌性SCID小鼠中,palifosfamide lysine(100 mg/kg)连续三天静脉给药,平均重量损失小于15%,4周治疗后完全恢复到基线水平,连续三天高达100 mg/kg的剂量导致体重损失大于20%或死亡。在原位乳腺MX-1肿瘤异种移植NCR-nu / nu小鼠中,palifosfamide抑制超过80%的MX-1肿瘤生长,具有17%的完全抗肿瘤反应[2]。
参考文献:
[1]. Hingorani P, Zhang W, Piperdi S, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol, 2009, 64(4): 733-740.
[2]. Jones B, Komarnitsky P, Miller GT, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs, 2012, 23(2): 173-184
.Storage | Store at -20°C |
M.Wt | 221.02 |
Cas No. | 31645-39-3 |
Formula | C4H11Cl2N2O2P |
Synonyms | Isophosphoramide mustard;IPM;ZIO-201 |
Solubility | ≥22.1 mg/mL in DMSO; insoluble in EtOH; ≥19.4 mg/mL in H2O with gentle warming and ultrasonic |
Chemical Name | bis(2-chloroethylamino)phosphinic acid |
SDF | Download SDF |
Canonical SMILES | C(CCl)NP(=O)(NCCCl)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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