切换导航

p53 tumor suppressor fragment

现货
Catalog No.
A1083
调节细胞周期
组合的产品项目
规格价格库存 数量
1mg
¥ 500.00
现货
5mg
¥ 1,500.00
现货
10mg
¥ 2,500.00
现货
25mg
¥ 3,500.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

Background

p53 tumor suppressor fragment (232-240),(C41H67N11O14S4), a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene(1). p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation(2). p53 has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms:It can activate DNA repair proteins when DNA has sustained damage. It can induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition.It can initiate apoptosis, the programmed cell death, if DNA damage proves to be irreparable(3).

A1083_1 

Figurestructure of p53 tumor suppressor

A1083_2  

FigureThe p53 tumor suppressor pathway

Ref:

1. Cho, Y.; Gorina, S.; Jeffrey, P. D.; Pavletich, N. P. (1994). "Crystalstructure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations". Science 265 (5170): 346–355.

2. Read, A. P.; Strachan, T.. Human molecular genetics 2. New York: Wiley; 1999. ISBN 0-471-33061-2. Chapter 18: Cancer Genetics.

3. May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene. 1999;18(53):7621–36.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1066.3
FormulaC41H67N11O14S4
SynonymsH2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH
Solubility≥53.3mg/mL in DMSO
SDFDownload SDF
Canonical SMILESNC(CCCCN)C(NC(CC1=CC=C(O)C=C1)C(NC(CCSC)C(NC(CS)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(NC(CS)C(NC(CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制