p53 tumor suppressor fragment
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
p53肿瘤抑制片段（232-240）C41H67N11O14S4，是一种多肽，序列为 H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH，分子量（MW）为1066.3。p53也被称为蛋白53或肿瘤蛋白53，是由人体内TP53基因编码的肿瘤抑制蛋白（1）。p53对多细胞生物十分重要，它可以调节细胞周期，作为肿瘤抑制剂参与癌症的预防。p53被定义为“基因组的守护者”，它可以通过防止基因组突变保证基因组的稳定性（2）。p53通过多种机制发挥抗癌作用，并参与细胞凋亡、基因组的稳定性和抑制血管生成。它的抗癌机制包括：当DNA受到持续伤害时可以激活DNA修复蛋白；识别DNA损伤时，诱导细胞周期停滞在G1 / S期调节点；如果DNA损伤无法弥补，可启动细胞凋亡和程序性细胞死亡（3）。
Figure1 structure of p53 tumor suppressor
Figure2 The p53 tumor suppressor pathway
参考文献：
1. Cho, Y.; Gorina, S.; Jeffrey, P. D.; Pavletich, N. P. (1994). "Crystalstructure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations". Science 265 (5170): 346–355.
2. Read, A. P.; Strachan, T.. Human molecular genetics 2. New York: Wiley; 1999. ISBN 0-471-33061-2. Chapter 18: Cancer Genetics.
3. May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene. 1999;18(53):7621–36.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1066.3 |
| Formula | C41H67N11O14S4 |
| Synonyms | H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH |
| Solubility | ≥53.3 mg/mL in DMSO; insoluble in EtOH; ≥52.8 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | NC(CCCCN)C(NC(CC1=CC=C(O)C=C1)C(NC(CCSC)C(NC(CS)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(NC(CS)C(NC(CCSC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
