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p-Cresyl sulfate

现货
Catalog No.
A8895
与蛋白相结合的尿毒症保留溶质。
组合的产品项目
规格价格库存 数量
10mg
¥ 3,500.00
现货
300mg
¥ 32,000.00
现货

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Background

The p-Cresol is a protein-bound uremic retention solute 1.

Free p-Cresol was found to be a cardiovascular risk factor in non-diabetic hemodialysis patients. In patients with diabetes, the level of both free p-cresol and total p-cresol were markedly higher. In patients treated by hemodialysis, the levels of these two forms of p-cresol were also significantly higher than that of patients treated by hemodiafiltration. The univariate cox proportional hazard analysis showed that the concentration of free p-cresol was obviously associated with cardiovascular disease (CVD). Quite many patients with high free p-cresol concentrations had new fatal or non-fatal cardiovascular events. Besides that, p-cresol was also found to inhibit cell proliferation. It inhibited the proliferation of cultured endothelial cells by 26% without affecting cell viability. Moreover, p-cresol treatment reduced endothelial wound repair by 19%, 28% and 40% at concentrations of 10, 25 and 50 μg/ml, respectively 1,2.

References:
1. Meijers B K I, Bammens B, De Moor B, et al. Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney international, 2008, 73(10): 1174-1180.
2. Dou L, Bertrand E, Cerini C, et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney international, 2004, 65(2): 442-451.

文献引用

1. Potts DM, Peterson DG. "Identification of small molecule flavor compounds that contribute to the somatosensory attributes of bovine milk products." Food Chem. 2019 Oct 1;294:27-34. PMID:31126463
2. Shi Y, Zhang Y, et al. "Improved dialytic removal of protein-bound uremic toxins by intravenous lipid emulsion in chronic kidney disease rats." Nephrol Dial Transplant. 2019 May 9. pii: gfz079. PMID:31071223
3. Shi Y, Tian H, et al. "Effect of Ionic Strength, pH and Chemical Displacers on the Percentage Protein Binding of Protein-Bound Uremic Toxins." Blood Purif. 2018 Dec 18:1-10. PMID:30562731
4. Shi Y, Wang Y, et al. "Increasing the removal of protein-bound uremic toxins by liposome-supported hemodialysis."Artif Organs. 2018 Oct 30. PMID:30375673

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
该产品在溶液中不稳定,建议现配现用
M.Wt188.20
Cas No.3233-58-7
FormulaC7H8O4S
Solubility≥30.1mg/mL in DMSO, ≥50mg/mL in H2O
Chemical Namep-tolyl hydrogen sulfate
SDFDownload SDF
Canonical SMILESCC1=CC=C(OS(O)(=O)=O)C=C1
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

细胞实验: [1]

细胞系

人脐静脉内皮细胞

制备方法

溶解度有限,若配制更高浓度的溶液,一般步骤如下:请将试管置于37℃加热10分钟和/或将其置于超声波浴中震荡一段时间。原液于-20℃可放置数月。

反应条件

24 h

实验结果

在含有和不含HAS的条件下,10 ug/mL、25 ug/mL和50 ug/mL p-cresol分别将内皮细胞的增殖减少21%、38%和54%。没有HAS存在的条件下,用p-cresol处理的单层中的内皮伤口修复明显低于对照组培养基处理的细胞。10 μg/mL、25 μg/mL和50 μg/mL p-cresol分别将内皮伤口修复减少19%、28%和40%。使用HSA,仅50 μg/mL p-cresol明显阻断内皮伤口修复。

动物实验: [2]

动物模型

肾功能正常和减少的大鼠

给药剂量

静脉注射p-cresol (10 mg/kg)

制备方法

溶于等渗盐水中

实验结果

在肾功能正常和降低的小鼠中注射p-cresol,并与在类似条件下获得的肌酐(60 mg/kg)的结果进行比较。在肾功能降低的大鼠中,与具有正常肾功能的大鼠相比,肾功能下降的大鼠中p-cresol的血清浓度显示出最小的下降。在肾功能正常的大鼠中,注射的p-cresol有21.0 ± 10.0%经尿排出。在肾衰竭的大鼠中,量为6.7 ± 7.5%。

注意事项

请于室内测试所有化合物的溶解度。虽然化合物的实际溶解度可能与其理论值略有不同,但仍处于实验系统误差的允许范围内。

References:

1. Dou L, Bertrand E, Cerini C, et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney international, 2004, 65(2): 442-451.

2. Lesaffer G, De Smet R, D'Heuvaert T et al. Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure. Kidney Int. 2003 Oct; 64(4):1365-73.

质量控制

化学结构

p-Cresyl sulfate

相关生物数据

p-Cresyl sulfate

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p-Cresyl sulfate

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p-Cresyl sulfate

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p-Cresyl sulfate