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p-Chlorophenylalanine

DL-4-氯苯丙氨酸
Catalog No.
B5036
不可逆结合色氨酸羟化酶的化合物
组合的产品项目
规格价格库存 数量
1g
¥ 454.00
Ship with 10-15 days

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A

背景

p-Chlorophenylalanine is a selective irreversible inhibitor of tryptophan hydroxylase. Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine). p-Chlorophenylalanine can deplete endogenous serotonin levels.

p-Chlorophenylalanine significantly attenuates pulmonary vascular remodeling and lung inflammation induced by MCT (Wild Lily), inhibits Tph-1 and SERT, MMP-2/ -9, TIMP-1/-2. Expression of IL-1β, TNF-α, ICAM-1. p-Chlorophenylalanine inhibits 5-HT by inhibiting Tph-1, regulating SERT and serotonin downstream signaling pathways.

Reference:

[1]. Bai Y, Wang H, Liu M, et al. 4-Chloro-DL-phenylalanine protects against monocrotalineinduced pulmonary vascular remodeling and lung inflammation. International Journal of Molecular Medicine, 2014, 33(2): 373-382.

文献引用

化学属性

Physical AppearanceA solid
StorageStore at RT
M.Wt199.64
Cas No.7424-00-2
FormulaC9H10ClNO2
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥4.58 mg/mL in H2O with gentle warming and ultrasonic
Chemical Name(R)-2-amino-3-(4-chlorophenyl)propanoic acid
SDFDownload SDF
Canonical SMILESClC1=CC=C(C=C1)C[C@H](C(O)=O)N
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