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OU749

 
Catalog No.
C4135
γ-谷氨酰转移酶(GGT)抑制剂
组合的产品项目
规格价格库存 数量
5mg
¥ 1,950.00
Ship with 10-15 days
10mg
¥ 3,033.00
Ship with 10-15 days
25mg
¥ 5,741.00
Ship with 10-15 days

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A

背景

OU749 is a competitive inhibitor of γ-glutamyl transpeptidase (GGT) [1].

Expression of γ-glutamyl transpeptidase (GGT) in tumors contributes to the resistance to radiation and chemotherapy. GGT is inhibited by glutamine analogues which compete with the substrate for the γ-glutamyl binding site [1].

OU749 inhibited human kidney GGT with an intrinsic Ki of 17.6 M [1]. In 786-O cells, a human renal tumor cell line, OU749 showed more than 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibited GGT isolated from human kidney in a dose-dependent manner [1]. OU749 was 7-fold less potent as inhibitor of GGT isolated from rat kidney and 10-fold less potent inhibiting GGT from mouse kidney [1]. OU749 did not inhibit degradation of glutathione by GGT from rat kidney. Inhibition of GGT by OU749 is species-specific [1]. OU749 showed no inhibitory effect on GGT from pig cells. OU749 inhibited human GGT expressed in mouse fibroblasts by a similar extent to the GGT from human cells, indicated that the species specificity was determined by differences in the primary structure of the protein rather than species-specific, post-translational modifications [1].

Reference:
[1] King J B, West M B, Cook P F, et al.  A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase[J]. Journal of Biological Chemistry, 2009, 284(14): 9059-9065.

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt361.4
Cas No.519170-13-9
FormulaC16H15N3O3S2
Solubility≤5mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical NameN-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-benzenesulfonamide
SDFDownload SDF
Canonical SMILESCOC1=CC=C(CC2=NN=C(NS(C3=CC=CC=C3)(=O)=O)S2)C=C1
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制

质量控制和MSDS

批次:

化学结构

OU749