Oltipraz
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Oltipraz是合成的1,2-二硫-3-硫酮,最初用于人的抗血吸虫药.动物研究表明,Oltipraz有效地诱导II期解毒酶,特别是谷胱甘肽-S-转移酶(GST).
体外:Oltipraz有利于提高II期解毒酶,而仅稍微改变I期”激活”酶的表达,因而Oltipraz属于单功能诱导剂.在芳香烃受体功能缺陷的Hepa-1c1c7细胞中,虽然醌还原酶需要双功能诱导剂诱导,但Oltipraz也能有效地诱导醌还原酶[1].
体内:在大鼠中,饮食浓度的Oltipraz有效地抑制Aflatoxin B1诱导的肝肿瘤发生.当更多黄曲霉毒素-谷胱甘肽偶联物经胆汁消除时,肝Aflatoxin-DNA加合物与血清Aflatoxin-白蛋白加合物水平随之下降,因而提供了用于预防疾病的生物标志物.其它动物研究表明,Oltipraz抑制化学致癌物诱导的膀胱癌\结肠癌\乳腺癌\胃癌以及皮肤癌[2].
临床试验:在I期临床试验中,正常志愿者口服单剂量Oltipraz(125\250\375和500 mg).4个剂量水平之间的半衰期以及125和250 mg剂量水平之间的清除率无显著差异.此外,在一系列小型试验中,持续28天的单剂量口服Oltipraz表明较短的半衰期(4.1 ~ 5.3小时);患者接受负荷剂量后无变化,进入持续稳定状态;在高脂肪饮食的患者中,Oltipraz在血清与尿液中的浓度增加[2].
参考文献:
[1] Clapper ML. Chemopreventive activity of oltipraz. Pharmacol Ther. 1998 Apr;78(1):17-27.
[2] Benson AB 3rd. Oltipraz: a laboratory and clinical review. J Cell Biochem Suppl. 1993;17F:278-91.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 226.34 |
Cas No. | 64224-21-1 |
Formula | C8H6N2S3 |
Solubility | ≥22.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
Chemical Name | 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
SDF | Download SDF |
Canonical SMILES | CC(C1=S)=C(SS1)C2=CN=CC=N2 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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