NVP-ADW742
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NVP-ADW742是一种新的IFG-1受体(IGF-1R)激酶抑制剂,IC50值为0.17 μM[1].
NVP-ADW742对IGF-1R比对胰岛素受体(InsR)更有效(超过16倍).此外,NVP-ADW742也可抑制其他激酶,对HER2\PDGFR\VEGFR-2或Bcr-Abl p210的IC50值大于10 μM,对c-Kit的IC50值大于5 μM[1].另外,在针对包括H526\H146\WBA和H209细胞系的小细胞肺癌(SCLC)的MTT试验中,NVP-ADW742与依托泊苷和卡铂联合使用可抑制细胞生长,诱发细胞毒性.除此之外,NVP-ADW742可完全抑制H526细胞中IGF-I诱导的VEGF mRNA表达[2].
参考文献:
[1] Mitsiades CS1, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M, Hideshima T, Chauhan D, Joseph M, Libermann TA, García-Echeverría C, Pearson MA, Hofmann F, Anderson KC, Kung AL. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors . Cancer Cell. 2004 Mar; 5(3):221-30.
[2]Warshamana-Greene GS1, Litz J, Buchdunger E, García-Echeverría C, Hofmann F, Krystal GW. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin Cancer Res. 2005 Feb 15;11(4):1563-71.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 453.58 |
Cas No. | 475488-23-4 |
Formula | C28H31N5O |
Solubility | Soluble in DMSO |
Chemical Name | 5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine |
SDF | Download SDF |
Canonical SMILES | C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Description | NVP-ADW742是一种IGF-1R的选择性抑制剂,IC50值为0.17 μM. | |||||
靶点 | IGF-1R | |||||
IC50 | 0.17 μM |