Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
一氧化氮合酶(NOSs)是一种催化L-精氨酸产生一氧化氮(NO)的酶。NO是一种重要的细胞内信号分子,帮助调节血管张力、胰岛素分泌、气道张力和蠕动,参与血管发生和神经发育。NOS主要存在三种亚型:(a)大脑中高浓度的可溶性组成性表达酶(bNOS、nNOS或NOS-1);(b)组成性表达的内皮细胞膜结合酶(eNOS或NOS-3);(c)与巨噬细胞的细胞毒性功能相关的诱导酶(iNOS或NOS-2) [1]。
一氧化氮合酶(599-613)阻断肽是一种来源于牛内皮细胞的多肽,氨基酸序列为Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys,抑制NOSs的功能,阻断NO生成。3种NOS同工酶参与不同方面的信号转导,NOS抑制剂在缺血再灌注损伤的管理、药物的降血压效果和细胞因子的炎性应答中得到重视[2,3]。
参考文献:
1. Achike, F.I., and Kwan, C.Y. 2003. Clin. Exp. Pharmacol. Physiol. 30, 605.
2. Chu, C.J., et al. 2000. Clin. Sci. 99, 475.
3.Mori. M., and Gotoh, T. 2000. Biochem. Biophys. Res. Commun. 275, 715.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 1963.13 |
Formula | C85H127N25O27S |
Synonyms | Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys-OH |
Solubility | ≥196.3 mg/mL in DMSO; ≥53.8 mg/mL in EtOH; ≥60.1 mg/mL in H2O |
SDF | Download SDF |
Canonical SMILES | O=C(NC(CC1=CC=C(O)C=C1)C(NC(CC(N)=O)C(NC(CO)C(NC(CO)C(N2CCCC2C(NC(CCCNC(N)=N)C(N3CCCC3C(NC(CCC(O)=O)C(NC(CCC(N)=O)C(NC(CC4=CN=CN4)C(NC(CCCCN)C(NC(CO)C(NC(CC5=CC=C(O)C=C5)C(NC(CCCCN)C(NC(CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C6CCCN6C(C)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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