Nelarabine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Nelarabine是一种新型的ara-G（9-β-D-阿拉伯呋喃糖基鸟嘌呤）前体药物，可用于治疗T-细胞淋巴母细胞淋巴瘤（T-LBL）和T细胞急性淋巴细胞白血病（T-ALL），不具有化疗方案治疗的术后反应[1]。
Nelarabine作为一种抑制剂，抑制DNA的合成，作为诱导剂，诱导恶性细胞中细胞凋亡。Nelarabine需要通过血浆中腺苷脱氨酶（ADA）的去甲基化形成活性化合物ara-G，通过细胞内脱氧鸟苷激酶和脱氧胞苷激酶磷酸化ara-G形成其三磷酸形式ara-GTP。在细胞内， ara-GTP比ara-G或nelarabine的含量高得多。ara-GTP取代 GTP可抑制DNA合成，导致凋亡性细胞死亡。这个过程对恶性T细胞以及其他快速复制的细胞是致死的[2]。
参考文献：
[1] Cohen MH, Johnson JR, Massie T, et al. Approval summary: nelarabine for the treatment of T-cell lymphoblastic leukemia/lymphoma. Clin Cancer Res. September 2006. 18:5329–35.
[2] Yesid Alvarado, Mary Alma Welch, Ronan Swords, John Bruzzi, Ellen Schlette, Francis J. Giles. Nelarabine activity in acute biphenotypic leukemia. Leukemia Research. November 2007. 31(11): 1600-1603.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 297.27 |
| Cas No. | 121032-29-9 |
| Formula | C11H15N5O5 |
| Solubility | insoluble in EtOH; ≥14.85 mg/mL in DMSO; ≥2.77 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | (2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| SDF | Download SDF |
| Canonical SMILES | COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
