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Myelin Basic Protein (87-99)

现货
Catalog No.
A1040
脑炎肽
组合的产品项目
规格价格库存 数量
1mg
¥ 800.00
现货
5mg
¥ 2,400.00
现货
10mg
¥ 4,000.00
现货
25mg
¥ 5,600.00
现货

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Background

The basic protein is a major structural protein of the central nervous system myelin in which it constitutes 30% of the total protein.(1)

T lymphocyte cell lines selected with whole MBP typically recognize only 1-3 immunodominant epitopes (Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al., 1988; McCarron and McFarlin, 1988) and these immunodominant MBP epitopes frequently are cncephalitogenic (Vandenbark et al., 1985b, 1989; Hashim et al., 1991). Thus, the identification of immunodominant MBP epitopes is likely to provide an in vitro method of identifying unrecognized enccphalitogenic epitopes of MBP. (2)

Although the cause of multiple sclerosis (MS) is not known, a T cell-mediated autoimmune process has been postulated. Myelin basic protein (MBP) is a potential target antigen because it induces experimental allergic encephalomyelitis (EAE) in susceptible animals. Encephalitogenic epitopes of MBP differ among susceptible strains and correlate with the MHC class II genotype. (3)

Figure1. Structure of Myelin Basic Protein

 A1040_1

Figure2. Formula of Myelin Basic Protein (87-99)

 A1040_2

Ref:

1. EYLAR, E. H., in L.Rowland (Editor), Immunologic disorders of the nervous system, Academic  Press, New York, 1971, Chapter 5.

2. Jones et al (1992) the synthetic 87-99 peptide of myelin basic protein is encelphalitogenic in Buffalo rats. J.Neuroimmunol. 37 203

3. Fritz, R., and D.E. McFarlin . 1989. Encephalitogenic epitopes 10. Richert, J., E.D. Robinson, G.E . Deibler, R.E. Martenson, of myelin basic protein. Chem. Immunol. 46:101.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1555.8
Cas No.118506-26-6
FormulaC74H114N20O17
SynonymsVal-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro
Solubility≥77.8 mg/mL in DMSO, ≥15.97 mg/mL in EtOH with ultrasonic and warming, ≥50.7 mg/mL in H2O
Chemical NameMyelin Basic Protein (87-99)
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)O)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CN=CN5)NC(=O)C(C(C)C)N
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